Synthesis of novel naphthyl substituted fused indazolonols as potent anticandidal agents.

OBJECTIVES A new series of naphthyl substituted indazolonols 15-21 were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1H, D2O exchanged 1H and 13C NMR spectroscopic data. METHODS All the synthesized compounds 15-21 were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida tropicalis and Candida parapsilosis. RESULTS A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F, -Cl, Br and -NO2) functional group substituted phenyl rings of novel naphthyl substituted indazolonols 15-21 exerted strong anticandidal activity against all the tested Candida species. CONCLUSIONS Compounds 17, 19-21 exhibit MIC value in the range of 6.25-200 microg/mL against all the tested candida species.